发明名称 |
METHODS FOR INCREASING OR DECREASING BONE DENSITY AND IDENTIFYING MOLECULES |
摘要 |
The SOST gene gives rise to sclerostin, a protein that leads to apoptosis of bone progenitor cells. The invention provides methods for identifying molecules that can depress expression of the SOST gene. The invention also provides methods for identifying new sclerostin antagonists. Such molecules and antagonists are useful for increasing bone mineralization in mammals, for example, in the treatment of osteoporosis. |
申请公布号 |
HK1153648(A1) |
申请公布日期 |
2013.04.12 |
申请号 |
HK20110107767 |
申请日期 |
2011.07.26 |
申请人 |
UCB MANUFACTURING INC.;KUNG SUTHERLAND MAY S.;GEOGHEGAN JAMES C.;YU CHANGPU;LATHAM JOHN |
发明人 |
KUNG SUTHERLAND, MAY S.;GEOGHEGAN, JAMES C.;YU, CHANGPU;LATHAM, JOHN |
分类号 |
G01N33/50;A61K31/557;A61K31/5575;A61K31/56;A61K31/573;A61K31/575;A61K31/7105;A61K38/00;A61K38/40;A61K48/00;A61P;A61P19/10;C12N15/09;C12N15/113;C12Q;C12Q1/04;C12Q1/68;G01N;G01N33/15 |
主分类号 |
G01N33/50 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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