发明名称 |
APTAMER BIOCONJUGATE DRUG DELIVERY DEVICE |
摘要 |
A delivery device for an active agent comprises nanoparticles based on a biopolymer such as starch. The delivery device may also be in the form of an aptamer-biopolymer-active agent conjugate wherein the aptamer targets the device for the treatment of specific disorders. The nanoparticles may be made by applying a high shear force in the presence of a crosslinker. The particles may be predominantly in the range of 50-150 nm and form a colloidal dispersion of crosslinked hydrogel particles in water. The biopolymer may be functionalized. The aptamer may be conjugated directly to the cross-linked biopolymers. The active agent may be a drug useful for the treatment of cancer. The delivery device survives for a period of time in the body sufficient to allow for the sustained release of a drug and for the transportation and uptake of the conjugate into targeted cells. However, the biopolymer is biocompatible and resorbable.
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申请公布号 |
US2013090467(A1) |
申请公布日期 |
2013.04.11 |
申请号 |
US201213614120 |
申请日期 |
2012.09.13 |
申请人 |
BLOEMBERGEN STEVEN;MCLENNAN IAN J.;JONES NATHAN;WAGNER RYAN;GANESH SHERMON AAREET KRSNA;ELSAYED ABDEL RAHMAN;LIU JUEWEN;ECOSYNTHETIX LTD. |
发明人 |
BLOEMBERGEN STEVEN;MCLENNAN IAN J.;JONES NATHAN;WAGNER RYAN;GANESH SHERMON AAREET KRSNA;ELSAYED ABDEL RAHMAN;LIU JUEWEN |
分类号 |
C08B31/00 |
主分类号 |
C08B31/00 |
代理机构 |
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