PYRROLOPYRIMIDINE COMPOUNDS FOR THE TREATMENT OF CANCER
摘要
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemia (ALL) cells and a potential cause of ALL chemoresistance. Hence, we investigated whether the development of small molecule Mer inhibitors was possible. A first aspect of the present invention is a compound (sometimes referred to as an "active compound" herein) of Formula I, IA, or IB.
申请公布号
WO2013052417(A1)
申请公布日期
2013.04.11
申请号
WO2012US58298
申请日期
2012.10.01
申请人
THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL
发明人
WANG, XIAODONG;LIU, JING;YANG, CHAO;ZHANG, WEIHE;FRYE, STEPHEN;KIREEV, DMITRI