PHARMACEUTICAL COMPOSITION FOR ORAL ADMINISTRATION COMPRISING BISPHOSPHONIC ACID OR ITS SALT

摘要

The present invention provides a pharmaceutical composition for oral administration, comprising bisphosphonic acid or its pharmaceutically acceptable salt; and gelatin, polyvinylacetal diethylaminoacetate, or a mixture thereof as an absorption enhancer. The pharmaceutical composition according to the present invention remarkably increases gastrointestinal absorption of bisphosphonic acid or its salt, thereby accomplishing high bioavailability thereof. And also, because the pharmaceutical composition according to the present invention shows desired pharmacological effects at a significantly low dose of bisphosphonic acid or its salt, it can minimize any side effects originated from relatively high dose thereof.