| 摘要 |
The present invention relates to a combination of effective substances causing synergistic effects of multiple targeting, and to uses thereof. More particularly, the present invention relates to a composition for a functional health food; to a cosmetic composition; to a pain alleviating composition; and to a composition for treating/preventing itching or atopic dermatitis, wherein each composition contains, as active ingredients, two or more substances selected from a group consisting of (a) an antagonist to a 5-HT2(5-hydroxtryptamine subtype 2) receptor; (b) an antagonist to a P2X receptor; and (c) any one of an agonist to a glycine receptor, an antagonist to a glycine transporter (GlyT), an agonist to a gamma-aminobutyric acid (GABA) receptor, and an antagonist to GABA transporter 1 (GABA1). The multi-targeting complex composition (specifically, natural product complex composition) has synergistic effects, and thus a treatment using a combination of individual substances may achieve increased biological effects from the mechanisms which the individual substances involve. Thus, the multi-targeting complex composition may not only remarkably alleviate pain but may also increase effects of: alleviating symptoms of skin diseases such as itching and atopic dermatitis; preventing or ameliorating depression; relaxation; skin pore reduction; ameliorating wrinkles; skin regeneration; skin health; skin condition recovery; whitening; preventing or ameliorating athlete's foot; scalp health recovery and regeneration; stimulation of hair growth; prevention of premature gray hair; improving teeth or ameliorating periodontal diseases; etc. |
