THE USE OF INHIBITORS OF BRUTON'S TYROSINE KINASE (BTK)
摘要
Disclosed herein are methods for treating a cancer comprising: a. administering a Btk inhibitor to a subject sufficient to result in an increase or appearance in the blood of a subpopulation of lymphocytes defined by immunophenotyping; b. determining the expression profile of one or more biomarkers from one or more subpopulation of lymphocytes; and c. administering a second agent based on the determined expression profile.
申请公布号
EP2575818(A2)
申请公布日期
2013.04.10
申请号
EP20110790524
申请日期
2011.06.03
申请人
PHARMACYCLICS, INC.
发明人
BUGGY, JOSEPH, J.;ELIAS, LAURENCE;FYFE, GWEN;HEDRICK, ERIC;LOURY, DAVID, J.;MODY, TARAK, D.