NOVEL AMINO ALCOHOL CATIONIC LIPIDS FOR OLIGONUCLEOTIDE DELIVERY
摘要
<p>The instant invention provides for novel cationic lipids that can be used in combination with other lipid components such as cholesterol and PEG-lipids to form lipid nanoparticles with oligonucleotides. It is an object of the instant invention to provide a cationic lipid scaffold that is more efficacious than traditional cationic lipids. The present invention employs amino alcohols to enhance the efficiency of in vivo delivery of siRNA.</p>
申请公布号
EP2575895(A2)
申请公布日期
2013.04.10
申请号
EP20110787138
申请日期
2011.05.18
申请人
MERCK SHARP & DOHME CORP.
发明人
BUDZIK, BRIAN, W.;COLLETTI, STEVEN, L.;SEIFRIED, DARLA DANILE;STANTON, MATTHEW, G.;TIAN, LU