| 发明名称 | 一种稳定的雷贝拉唑钠化合物 | ||
| 摘要 | 本发明属于医药技术领域，具体涉及雷贝拉唑钠化合物及其制备方法，本发明得到的雷贝拉唑钠，水分极少，具有的优点：化学纯度99.9%，最大杂质小于1‰，光学纯度高达99.96%ee；稳定性好。本发明所述化合物生产成本低，质量稳定，适合工业化生产。 | ||
| 申请公布号 | CN102260244B | 申请公布日期 | 2013.04.10 |
| 申请号 | CN201110228091.0 | 申请日期 | 2011.08.10 |
| 申请人 | 天津市汉康医药生物技术有限公司 | 发明人 | 严洁;黄欣 |
| 分类号 | C07D401/12(2006.01)I;A61K31/4439(2006.01)I;A61P1/04(2006.01)I | 主分类号 | C07D401/12(2006.01)I |
| 代理机构 | 代理人 | ||
| 主权项 | 1.式Ⅰ所示的雷贝拉唑钠化合物的晶体，<img file="579658DEST_PATH_IMAGE001.GIF" wi="338" he="175" />所述雷贝拉唑钠化合物的晶体，用CuKa射线作为特征X射线粉末测定中，其图谱具有下列2θ衍射角和d值，<tables num="0001"><table><tgroup cols="4"><colspec colname="c001" colwidth="15%" /><colspec colname="c002" colwidth="45%" /><colspec colname="c003" colwidth="25%" /><colspec colname="c004" colwidth="13%" /><tbody><row><entry morerows="1">峰数</entry><entry morerows="1">2θ角（°）实测值</entry><entry morerows="1">d ()实测值</entry><entry morerows="1">I/I<sub>0</sub></entry></row><row><entry morerows="1">1</entry><entry morerows="1">4.920</entry><entry morerows="1">17.9461</entry><entry morerows="1">100</entry></row><row><entry morerows="1">2</entry><entry morerows="1">9.900</entry><entry morerows="1">8.9270</entry><entry morerows="1">38</entry></row><row><entry morerows="1">3</entry><entry morerows="1">11.700</entry><entry morerows="1">7.5574</entry><entry morerows="1">2</entry></row><row><entry morerows="1">4</entry><entry morerows="1">12.420</entry><entry morerows="1">7.1208</entry><entry morerows="1">1</entry></row><row><entry morerows="1">5</entry><entry morerows="1">14.920</entry><entry morerows="1">5.9328</entry><entry morerows="1">27</entry></row><row><entry morerows="1">6</entry><entry morerows="1">16.160</entry><entry morerows="1">5.4803</entry><entry morerows="1">2</entry></row><row><entry morerows="1">7</entry><entry morerows="1">18.280</entry><entry morerows="1">4.8492</entry><entry morerows="1">2</entry></row><row><entry morerows="1">8</entry><entry morerows="1">19.500</entry><entry morerows="1">4.5485</entry><entry morerows="1">80</entry></row><row><entry morerows="1">9</entry><entry morerows="1">20.880</entry><entry morerows="1">4.2509</entry><entry morerows="1">4</entry></row><row><entry morerows="1">10</entry><entry morerows="1">22.640</entry><entry morerows="1">3.9242</entry><entry morerows="1">2</entry></row><row><entry morerows="1">11</entry><entry morerows="1">23.360</entry><entry morerows="1">3.8049</entry><entry morerows="1">6</entry></row><row><entry morerows="1">12</entry><entry morerows="1">24.340</entry><entry morerows="1">3.6539</entry><entry morerows="1">4</entry></row><row><entry morerows="1">13</entry><entry morerows="1">24.740</entry><entry morerows="1">3.5957</entry><entry morerows="1">4</entry></row><row><entry morerows="1">14</entry><entry morerows="1">25.120</entry><entry morerows="1">3.5421</entry><entry morerows="1">3</entry></row><row><entry morerows="1">15</entry><entry morerows="1">26.240</entry><entry morerows="1">3.3934</entry><entry morerows="1">4</entry></row><row><entry morerows="1">16</entry><entry morerows="1">26.580</entry><entry morerows="1">3.3508</entry><entry morerows="1">4</entry></row><row><entry morerows="1">17</entry><entry morerows="1">27.980</entry><entry morerows="1">3.1862</entry><entry morerows="1">3</entry></row><row><entry morerows="1">18</entry><entry morerows="1">29.000</entry><entry morerows="1">3.0764</entry><entry morerows="1">3</entry></row><row><entry morerows="1">19</entry><entry morerows="1">30.220</entry><entry morerows="1">2.9550</entry><entry morerows="1">7</entry></row><row><entry morerows="1">20</entry><entry morerows="1">30.440</entry><entry morerows="1">2.9341</entry><entry morerows="1">5</entry></row></tbody></tgroup></table></tables>2θ衍射角的误差为±0.2。 | ||
| 地址 | 300203 天津市河西区大沽南路敬重里4号3层 | ||