| 摘要 |
FIELD: chemistry.SUBSTANCE: present invention relates to a novel method for synthesis of (Z)-3-[2-butoxy-3'-(3-heptyl-1-methylureido)biphenyl-4-yl]-2-methoxyacrylic acid of formula(I) and intermediate compounds(XII),(XIII) and(XIV). The disclosed method involves reaction of a sulphonate of formula (XII), where Rdenotes methyl, trifluoromethyl, phenyl or tolyl, with 3-heptyl-1-methyl-1-[3-(4,4,5,5-tetramethyl[1,3,2]dioxaborolan-2-yl)phenyl]urea of formula(IIIb) or with a corresponding boronic acid of formula(IIIa).EFFECT: easier synthesis owing to fewer steps.8 cl, 1 ex, 2 dwg |
