摘要 |
FIELD: medicine, pharmaceutics.SUBSTANCE: present invention refers to spirocyclic nitriles of formula(1a): wherein the radicals A, B, C, X, Y, R24, R25, R26 and R27 are presented in cl.1 of the patent claim, inhibiting thiol proteases, particularly cathepsins, a method for preparing and using them as a drug for treating the diseases directly or indirectly mediated by cathepsins.EFFECT: preparing the agent for treating the diseases directly or indirectly mediated by cathepsins.12 cl, 2 tbl, 105 ex |