PROCESS FOR PREPARING OLIGONUCLEOTIDES

摘要

A process for the preparation of an oligonucleotide is provided. The process
comprises the assembly of an oligonucleotide attached to a solid support,
wherein the solid support is prepared by a process comprising polymerisation
of a monomer which comprises a protected hydroxypolyC2-4 alkyleneoxy chain
attached to a polymerisable unit wherein the protected hydroxypolyC2-
4alkyleneoxy chain contains from 2 to 10 C2-4 alkyleneoxy groups and wherein
the hydroxypolyC2-4 alkyleneoxy chain is protected with an acid-labile
protecting group, preferably an optionally substituted trityl group.