THERAPEUTIC USE OF GELATIN HYDROGELS WITH A GEL-SOL TRANSITION AT BODY TEMPERATURE

摘要

The invention regards the use of gelatin hydrogels that are solid at room temperature and melt or present a gel-sol transition at temperatures near the body temperature, so assuming a liquid state when put contact with body, implanted in the body or heated at temperatures compatible with the body. The gelatin-based hydrogels may contain biologically active agents and/or cells that after hydrogel melting or gel-sol transition, are fast released in situ, thus explicating the therapeutic and biological action. The gelatin-based hydrogels, containing or not containing biologically active agents, may be solid at the temperature of the skin (33°C) and melt when water or aqueous solution at a temperature compatible to the body is poured onto for an easy removal of the hydrogels.