| 发明名称 |
INHIBITORS OF CATECHOL O-METHYL TRANSFERASE AND THEIR USE IN THE TREATMENT OF PSYCHOTIC DISORDERS |
| 摘要 |
The present invention relates to 4-pyridinone compounds which are inhibitors of catechol O-methyltransferase (COMT), and are useful in the treatment and prevention of neurological and psychiatric disorders and diseases in which COMT enzyme is involved. The present invention also relates to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which COMT is involved.
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| 申请公布号 |
US2013084346(A1) |
申请公布日期 |
2013.04.04 |
| 申请号 |
US201113582601 |
申请日期 |
2011.02.28 |
| 申请人 |
WOLKENBERG SCOTT;BARROW JAMES C.;POSLUSNEY MICHAEL S.;HARRISON SCOTT T.;TROTTER B. WESLEY;MULHEARN JAMES;NANDA KAUSIK K.;MANLEY PETER J.;ZHAO ZHIJIAN;SCHUBERT JEFFREY W.;KETT NATHAN;ZARTMAN AMY |
发明人 |
WOLKENBERG SCOTT;BARROW JAMES C.;POSLUSNEY MICHAEL S.;HARRISON SCOTT T.;TROTTER B. WESLEY;MULHEARN JAMES;NANDA KAUSIK K.;MANLEY PETER J.;ZHAO ZHIJIAN;SCHUBERT JEFFREY W.;KETT NATHAN;ZARTMAN AMY |
| 分类号 |
C07D213/69;A61K31/4418;A61K31/4439;A61K31/444;A61K31/4545;A61K31/4709;A61K31/4725;A61K31/5377;A61K31/541;A61K31/69;A61K45/06;C07D213/73;C07D213/74;C07D401/10;C07D401/14;C07D413/10;C07D413/12;C07D417/10;C07D471/04;C07F5/02 |
主分类号 |
C07D213/69 |
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