ANTIGEN-BINDING MOLECULE FOR PROMOTING LOSS OF ANTIGENS

摘要

The present invention provides antigen-binding molecules comprising: antigen-binding domains which have binding affinity to human FcRn under acidic pH conditions, and with which the binding affinity of the antigen-binding molecules to antigens is altered according to ion concentration conditions; and Fcgamma receptor-binding domains which have a higher binding affinity to Fcgamma receptors under neutral pH conditions than the Fcgamma receptor-binding domains of the Fc regions of natural human IgG having a fucose-containing sugar chain as the sugar chain bound to position 297 (EU numbering).