| 摘要 |
<P>PROBLEM TO BE SOLVED: To provide a recovery and purification process involving crystallization that can be used to crystallizable proteins in general. <P>SOLUTION: The present invention relates generally to Apo2L/TRAIL purification involving crystallization. Applicants surprisingly found that the unique molecular structure of APO2L/TRA1L, under certain conditions, allows it to spontaneously crystallize. This property enabled the development of an efficient and scaleable recovery/purification process for APO2L/TRAIL that utilizes crystallization as a purification step. In addition, the experience obtained with APO2L/TRAIL allows the development of the recovery and purification process involving crystallization that can be used to the crystallizable proteins in general. <P>COPYRIGHT: (C)2013,JPO&INPIT |
