发明名称 Pyripyropene Derivative Having ACAT2 Inhibiting Activity and Stable to Metabolizing Enzymes
摘要 A compound effective in prevention and treatment of arteriosclerosis with a mechanism different from that of statin drugs has the following formula or a pharmaceutically acceptable salt, solvate, or hydrate thereof: wherein R1 is an aliphatic, alicyclic, or aromatic acyloxy group, or a group of the formula —13—O—CH(R7)—R8 where R7 is a lower alkoxy group and R8 is an aryl group, and R2 is carboxyl, a lower alkoxycarbonyl group, or an arylmethylcarbamoyl group, or a —CH2-acyloxy group and R3 is an aliphatic, alicyclic or aromatic acyloxy group, provided that at least one of R4 and R3 is a group other than acetoxy, or R2 and R3 taken together form a group of the formula —O—CH(R5)—O— where R5 is an aryl group.
申请公布号 US2013085163(A1) 申请公布日期 2013.04.04
申请号 US201113638332 申请日期 2011.03.25
申请人 TOMODA HIROSHI;NAGAMITSU TOHRU;MATSUDA DAISUKE;OHSHIRO TAICHI;OHTAWA MASAKI;OMURA SATOSHI;SCHOOL JURIDICAL PERSON KITASATO INSTITUTE 发明人 TOMODA HIROSHI;NAGAMITSU TOHRU;MATSUDA DAISUKE;OHSHIRO TAICHI;OHTAWA MASAKI;OMURA SATOSHI
分类号 C07D493/14;C07D493/04 主分类号 C07D493/14
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