FACTOR VIIa-(POLY)SIALIC ACID CONJUGATE HAVING PROLONGED in vivo HALF-LIFE

摘要

PROBLEM TO BE SOLVED: To provide a factor VIIa-polysialic acid conjugate having a prolonged in vivo half-life.

SOLUTION: The present invention relates to a proteinaceous construct comprising plasmatic or recombinant factor VIIa (FVIIa) or biologically active derivatives thereof, which are bound to a chain comprising 1-4 sialic acid units, wherein the in vivo half-life of the proteinaceous construct is substantially prolonged in the blood of a mammal, especially a human, as compared to the in vivo half-life of a FVIIa deficient in the chain comprising 1-4 sialic acid units or a derivative thereof.

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