摘要 |
The present invention relates to compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; solid forms of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors. The compounds of this invention have formula I-l : wherein the variables are as defined herein. Additionally, the compounds of this invention have formula II: or a pharmaceutically acceptable salt thereof, wherein the variables are as defined herein. |
申请人 |
VERTEX PHARMACEUTICALS INCORPORATED |
发明人 |
CHARRIER, JEAN-DAMIEN;STORCK, PIERRE-HENRI;STUDLEY, JOHN;PIERARD, FRANCOISE YVONNE, THEODORA MARIE;DURRANT, STEVEN, JOHN;LITTLER, BENJAMIN, JOSEPH;ANGELL, PAUL;HUGHES, ROBERT, MICHAEL;SIESEL, DAVID, ANDREW;URBINA, ARMANDO;ZWICKER, CARL;LOCONTE, NICHOLAS;BARDER, TIMOTHY |