发明名称 |
METHOD OF TREATING CANCER USING COMBINATION OF BRAF INHIBITOR, MEK INHIBITOR, AND ANTI-CTLA-4 ANTIBODY |
摘要 |
A combination of anti-neoplastic agents that provides increased activity over monotherapy. In particular, the drug combination that includes an anti-CTLA-4 antibody, in combination with the B-Raf inhibitor N-{3-[5-(2-Amino-4-pyrimidinyl)-2-(1,1-dimethylethyl)-1,3-thiazol-4-yl]-2-fluorophenyl}-2,6-difluorobenzenesulfonamide, or a pharmaceutically acceptable salt thereof, and MEK inhibitor N-(3-{3-cyclopropyl-5-[(2-fluoro-4-iodophenyl)amino]-6,8-dimethyl-2,4,7-trioxo-3,4,6,7- tetrahydropyrido[4,3-d]pyrimidin-1(2H)-yl}phenyl)acetamide, or a pharmaceutically acceptable salt or solvate thereof is described. |
申请公布号 |
WO2013019620(A3) |
申请公布日期 |
2013.04.04 |
申请号 |
WO2012US48552 |
申请日期 |
2012.07.27 |
申请人 |
GLAXOSMITHKLINE LLC;LEGOS, JEFFREY, J.;CORNFELD, MARK, J. |
发明人 |
LEGOS, JEFFREY, J.;CORNFELD, MARK, J. |
分类号 |
A61K45/00;A61K31/54;A61K39/395 |
主分类号 |
A61K45/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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