Factor VII or Vlla Gla domain variants

摘要

FACTOR VII OR VIla GLA DOMAIN VARIANTS Abstract 5 Gla domain variants of human Factor VII or human Factor VIla, comprising 1-15 amino acid modifications relative to human Factor VII or human Factor VIla, wherein a hydrophobic amino acid residue has been introduced by substitution in position 34, or having an amino acid substitution in position 36, or having amino acid substitutions in positions 10 and 32 and at least one further amino acid substitution in a position selected 1o from 74, 77 and 116.