Described herein are polypeptides and related antibodies comprising a variant Fc domain. The variant Fc domain provide for stabilized Fc: Fc interactions when the polypeptide(s), antibody or antibodies are bound to its target, antigen or antigens on the surface of a cell, thus providing for improved effector functions, such as CDC- response.
申请公布号
WO2013004842(A3)
申请公布日期
2013.04.04
申请号
WO2012EP63339
申请日期
2012.07.06
申请人
GENMAB A/S;PARREN, PAUL;BEURSKENS, FRANK;DE JONG, ROB N.;LABRIJN, ARAN FRANK;SCHUURMAN, JANINE
发明人
PARREN, PAUL;BEURSKENS, FRANK;DE JONG, ROB N.;LABRIJN, ARAN FRANK;SCHUURMAN, JANINE