发明名称 |
MARKER FOR DIAGNOSING LIVER CANCER CONTAINING ANTI-ATIC AUTOANTIBODY, AND COMPOSITION FOR DIAGNOSING LIVER CANCER CONTAINING ANTIGEN THEREOF |
摘要 |
The present invention relates to a fragment comprising an autoantibody which specifically binds to ATIC or an antigen-binding site (i.e. paratope) of the autoantibody, a composition for diagnosing liver cancer containing an agent which measures the expression level of the fragment, a hybridoma cell line producing the autoantibody, a diagnostic kit for liver cancer containing the composition, a method for diagnosing liver using the composition, and a method for screening a liver cancer therapeutic agent using the autoantibody. Using the anti-ATIC specific autoantibody of the present invention as a marker for diagnosing liver cancer, the occurrence of liver cancer can be diagnosed using a non-invasive biological sample such as blood, plasma, serum, lymph tissue, and the like, with a sensitivity of about 87% and a specificity of about 88%, and as liver cancer can be easily diagnosed using an amino acid sequence identified in the present invention, the autoantibody is effective for developing a diagnostic kit for liver cancer. |
申请公布号 |
WO2012165926(A3) |
申请公布日期 |
2013.04.04 |
申请号 |
WO2012KR04396 |
申请日期 |
2012.06.04 |
申请人 |
KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY;CHO, EUN WIE;HEO, CHANG GYU;KO, JEONG HEON;WOO, MI KYUNG;YOO, HYANG SOOK;HWANG, HAI MIN |
发明人 |
CHO, EUN WIE;HEO, CHANG GYU;KO, JEONG HEON;WOO, MI KYUNG;YOO, HYANG SOOK;HWANG, HAI MIN |
分类号 |
C07K16/30;C12N5/16;G01N33/53;G01N33/574 |
主分类号 |
C07K16/30 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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