发明名称 |
COMPOSITION FOR TREATING BONE DISEASE COMPRISING A GLYCEOLLIN AS AN ACTIVE INGREDIENT |
摘要 |
A method for preventing or treating a bone disease, includes administering to a patient having the bone disease a pharmaceutical composition comprising glyceollin as an active ingredient. The active ingredient, glyceollin promotes degradation of the Runx2 protein in osteoblasts and inhibits the mRNA expression of Rankl in osteoblasts to prevent the differentiation of osteoclasts. Furthermore, glyceollin is capable of ameliorating osteoporosis in animal models for osteoporosis. The composition promises drug or food for prevention or treatment of not only osteoporosis but also bone diseases caused by cancer metastatic to the bone.
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申请公布号 |
US2013085178(A1) |
申请公布日期 |
2013.04.04 |
申请号 |
US201113643597 |
申请日期 |
2011.04.28 |
申请人 |
CHOI JE-YONG;HAN MIN-SU;JEONG JAE-HWAN;LIM KYUNG EUN;KIM YONG-HOON;HWANG YOUNG-HYUN;KIM IN-KYEOM;KYUNGPOOK NATIONAL UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION |
发明人 |
CHOI JE-YONG;HAN MIN-SU;JEONG JAE-HWAN;LIM KYUNG EUN;KIM YONG-HOON;HWANG YOUNG-HYUN;KIM IN-KYEOM |
分类号 |
A61K31/352 |
主分类号 |
A61K31/352 |
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