PROMOTER FOR EXPRESSION OF CLOCK GENE AND HYALURONIC ACID SYNTHASE GENE

摘要

[Problem] To promote the expression of a clock gene and a hyaluronic acid synthase gene in the skin more effectively. [Solution] A composition comprising one or both of a lavender oil and a eucalyptus oil and an alkylene oxide derivative represented by general formula (I) is applied to the skin. (In the formula, AO represents an oxyalkylene group having 3-4 carbon atoms; EO represents an oxyethylene group; m and n independently represent the average number of moles of the oxyalkylene groups each having 3-4 carbon atoms added and the average number of moles of the oxyethylene groups added, respectively, wherein 1 <= m <= 70 and 1 <= n <= 70; wherein the ratio of the content of the oxyethylene group is 20-80 mass% relative to the total content of the oxyalkylene group and the oxyethylene group. The oxyalkylene group and the oxyethylene group are added in the form of a block or randomly. R1 and R2 may be the same as or different from each other, and independently represent a hydrocarbon group having 1-4 carbon atoms or a hydrogen atom, wherein the ratio of the number of hydrogen atoms relative to the number of hydrocarbon atoms in R1 and R2 is 0.15 or less. R1-[(AO)m(EO)n]-R2 (I)