| 摘要 |
<p>Novel compounds of the formulae <FORM:1117782/C2/1> <FORM:1117782/C2/2> (wherein X1 is an ammonium cation, a C1- 4 alkyl radical or the group -(CH2)n-NRR1 in which n is 1, 2 or 3 and R and R1 are each hydrogen or C1- 4 alkyl) and acid-addition salts of the amino-esters are prepared (1) by reaction of nopinic acid with ammonia to give ammonium nopinate; (2) by esterification of nopinic acid or transesterification of its alkyl esters with alkanols or aminoalkanols to give corresponding esters of nopinic acid, or by reaction of alkali metal salts of nopinic acid with alkyl halides or aminoalkyl halides; and (3) by mixing nopinic acid and amino-alkanols in suitable solvents to give salts of nopinic acid with the amino-alkanols. Examples are given. The novel nopinic acid derivatives may be made up into pharmaceutical compositions for the prevention and control of ulcers and/or of pain due to ulcers. The compositions may be for peroral, topical or parentaral use.</p> |
