TEMPORARY, PHARMACOLOGICALLY-INACTIVE DENTAL COATING FOR THE IN SITU PROTECTION OF DENTAL THERAPEUTIC AGENTS FROM SALIVA AND ABRASION FROM CHEWING

摘要

Topical application of a pharmacologically-inactive, inert polymeric solution
to teeth affords a temporary, protective barrier for pharmacologically-active
compounds that have been previously applied topically to the tooth surfaces
for caries reduction. In a method of use, an aqueous dispersion
polymethylmethacrylate (PMMA) and a suitable plasticizer are applied topically
to the tooth surface immediately after the topical application of
chlorhexidine or fluoride. The inert coating thus formed is distinct from any
pharmacologically-active substance, and remains on the tooth surface until
abraded by the chewing of hard foods. In a composition of matter, the solution
contains ammonio methacrylate copolymer, type B USP/NF of between 20% and 35%
w/w; triethyl citrate USP/NF of between 1% and 10% w/w; and purified water of
between 60% and 70% w/w. The ammonio methacrylate copolymer is preferably
EUDRAGIT RS 30 D brand available form Rohm GmbH.