发明名称 |
Amide compounds, their pharmaceutical compositions, their preparation method and their uses |
摘要 |
The present invention pertains to the field of pharmaceutical chemistry and discloses 8-(3-aminopropyl)-3-exo-8-azabicyclo[3.2.1]octane-3-amino amide compounds represented by formula I, the pharmaceutical compositions, the preparation method and the use thereof. Such compounds or pharmaceutically acceptable salts thereof can be used as an antagonist of CCR5 in preparing medicaments for treating diseases mediated by CCR5, particularly HIV infection, asthma, rheumatoid arthritis, autoimmune diseases and chronic obstructive pulmonary diseases (COPD). |
申请公布号 |
US8410094(B2) |
申请公布日期 |
2013.04.02 |
申请号 |
US200913123455 |
申请日期 |
2009.09.18 |
申请人 |
LONG YAQIU;FAN XING;FENG DONGZHI;CHEN LI;CHEN RENHAI;SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES;SHANGHAI TARGETDRUG CO., LTD. |
发明人 |
LONG YAQIU;FAN XING;FENG DONGZHI;CHEN LI;CHEN RENHAI |
分类号 |
C07D451/04;A61K31/46 |
主分类号 |
C07D451/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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