| 发明名称 |
Modulation of eIF4E expression |
| 摘要 |
Oligomeric compounds, compositions and methods are provided for modulating the expression of eIF4E. The antisense compounds may be single- or double-stranded and are targeted to nucleic acid encoding eIF4E. Methods of using these compounds for modulation of eIF4E expression and for diagnosis and treatment of diseases and conditions associated with expression of eIF4E are provided.
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| 申请公布号 |
US8410074(B2) |
申请公布日期 |
2013.04.02 |
| 申请号 |
US201213548784 |
申请日期 |
2012.07.13 |
| 申请人 |
DOBIE KENNETH W.;MARCUSSON ERIC G.;SWAYZE ERIC E.;BHAT BALKRISHEN;GRAFF JEREMY RICHARD;ISIS PHARMACEUTICALS, INC. |
发明人 |
DOBIE KENNETH W.;MARCUSSON ERIC G.;SWAYZE ERIC E.;BHAT BALKRISHEN;GRAFF JEREMY RICHARD |
| 分类号 |
C07H21/02;A61K31/70;A61K38/00;C07H21/04;C12N15/113;C12Q1/68 |
主分类号 |
C07H21/02 |
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