CARBAZOLE DERIVATIVES, SOLVATES THEREOF, OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF

摘要

An object of the present invention is to provide novel carbazole derivatives,
solvates thereof, or pharmaceutically acceptable salts thereof having an
excellent
adipose tissue weight reducing effect, hypoglycemic effect, and hypolipidemic
effect,
which are useful as a preventive and/or therapeutic agent for fatty liver,
obesity, lipid
metabolism abnormality, visceral adiposity, diabetes, hyperlipemia, impaired
glucose
tolerance, hypertension, non-alcoholic fatty liver disease, non-alcoholic
steatohepatitis, and the like.
The above-mentioned object can be achieved by carbazole derivatives,
solvates thereof, or pharmaceutically acceptable salts thereof, wherein the
carbazole
derivatives are represented by the following general formula (I):

(see formula I)
(In the formula (I), the ring A represents phenyl group or the like; X
represents -O- or
the like; Y represents =N- or the like; a and b represent methylene group or
the like;
both V and Z represent -O- or the like; W represents a C1-C10 alkylene group
whose 1
or 2 hydrogen atoms may be substituted by a phenyl group or a C1-C6 alkyl
group;
1,2-phenylene group; 1,3-cyclohexyl group; or the like; R1 represents methyl
group or
the like; R2 represents methoxy group or the like; and R3 represents carboxy
group or
the like.)