| 摘要 |
LEPTOMYCIN DERIVATIVES HAVING A MOIETY, SUCH AS A SULFIDE OR A DISULFIDE, THAT CAN CONJUGATE TO A CELL BINDING REAGENT SUCH AS AN ANTIBODY ARE DISCLOSED. THE THERAPEUTIC USE OF SUCH LEPTOMYCIN DERIVATIVE CONJUGATES IS ALSO DESCRIBED; SUCH CONJUGATES HAVE THERAPEUTIC USE BECAUSE THEY CAN DELIVER CYTOTOXIC LEPTOMYCIN DERIVATIVES TO A SPECIFIC CELL POPULATION IN A TARGETED FASHION. |
