NEW CRYSTALLINE FORM VI OF AGOMELATINE, A PROCESS FOR ITS PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING IT

摘要

CRYSTALLINE FORM VI OF THE COMPOUND OF FORMULA (I): CHARACTERIZED BY THE FOLLOWING X-RAY POWDER DIFFRACTION DIAGRAM 2- Theta (0) d (A) Intensity (%) expo expo 5.73 15.411 11.4 10.22 8.645 11.6 20.10 4.413 10.2 23.69 3.751 59.0 29.48 3.027 14.8. MEASURED USING A DIFFRACTOMETER (COPPER ANTICATHODE) AND EXPRESSED IN TERMS OF INTERPLANAR DISTANCE D, BRAGG'S ANGLE 2 THETA AND RELATIVE INTENSITY (EXPRESSED AS A PERCENTAGE RELATIVE TO THE MOST INTENSE LINE) AND MEDICINAL PRODUCTS CONTAINING THE SAME WHICH ARE USEFUL IN TREATING MELATONINERGIC DISORDERS.