OXYGEN-TRANSFERRING BLOOD SUBSTITUTE AND A PHARMACEUTICAL COMPOSITION (VARIANTS)

摘要

The invention relates to medicine, in particular to polyhemoglobin-based blood substitutes. The invention can be used for producing blood substituting solutions comparable in terms of a gas transportation efficiency (oxygen transfer) with human blood erythrocytes. The inventive oxygen-transferring blood substitute is based on the hemoglobin which is polymerised by glutaraldehyde produced from animal blood and differs in that it is in the form of a dry substance and contains not less than 90% of polymerised hemoglobin, the molecular mass of which ranges from 192 000 to 320 000 Da and the methemoglobin content in the blood substitute is equal to or less than 5%.