发明名称 |
METHODS AND COMPOSITIONS BASED ON SHIGA TOXIN TYPE 2 PROTEIN |
摘要 |
593926 Provided is a composition for stimulating an immune response against Stx2, comprising a pharmaceutically acceptable carrier and at least one purified polypeptide with a specified sequence, inserted into a non-Stx2 protein scaffold, wherein said polypeptide has the antigenicity of Stx2, wherein said scaffold comprises a protein substantially identical to Stx1, or a functional fragment thereof. Further provided are antibodies directed to the polypeptides and their use in diagnosing or treating Shiga toxin associated diseases. |
申请公布号 |
NZ593926(A) |
申请公布日期 |
2013.03.28 |
申请号 |
NZ20100593926 |
申请日期 |
2010.01.21 |
申请人 |
THE HENRY M. JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE, INC. |
发明人 |
O'BRIEN, ALISON;MELTON-CELSA, ANGELA;SMITH, MICHAEL;SINCLAIR, JAMES |
分类号 |
A61K38/00;C07K14/00 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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