| 摘要 |
<P>PROBLEM TO BE SOLVED: To provide methods of remodeling and labeling proteins and antibodies at novel oligosaccharide linkages; and to provide antibodies or proteins linked to modified oligosaccharides. <P>SOLUTION: A step of attaching a modified sugar-containing chemical handle to a GlcNAc residue on a first protein, and a step of mixing the first protein with a reporter molecule, carrier molecule or solid support capable of reacting with the chemical handle are included. The reporter molecule, carrier molecule or solid support attaches to the protein at the chemical handle, thereby forming the glycomodified protein. The first protein is an antibody. <P>COPYRIGHT: (C)2013,JPO&INPIT |
