The invention provides a method for culturing mammalian cells. The method provides greater control over cell growth to achieve high product titer cell cultures by changing the temperature of the cell culture and/or by starving the cells in their asparagine supply.
申请公布号
WO2013006479(A3)
申请公布日期
2013.03.28
申请号
WO2012US45070
申请日期
2012.06.29
申请人
AMGEN INC.;FOLLSTAD, BRIAN, D.;MCCOY, REBECCA, E.;MORRIS, ARVIA, E.
发明人
FOLLSTAD, BRIAN, D.;MCCOY, REBECCA, E.;MORRIS, ARVIA, E.
