| 摘要 |
<p>A method of preparing a monodisperse oligo (ethylene glycol) reagent composition is disclosed, wherein the method comprises the step of reacting a halo-terminated oligo (ethylene glycol) having (m) monomer subunits with a hydroxyl-terminated oligo (ethylene glycol) having (n) monomer subunits under conditions effective to displace said halo group to thereby form an oligo (ethylene glycol) having (m) + (n) monomer subunits (OEGm+m), where (m) and (n) each independently range from 1-10, wherein the reacting step is carried out in the presence of a strong base such as sodium, potassium, sodium hydride, potassium hydride, sodium methoxide, potassium methoxide, sodium tert-butoxide, or potassium tert-butoxide, suitable for converting the hydroxyl group of the hydroxyl-terminated oligo(ethylene glycol) into the corresponding alkoxide.</p> |
