PREPARATION METHOD OF PRANLUKAST NANO SOLID DISPERSANT AND THE NANO SOLID DISPERSANT PREPARED THEREBY

摘要

PURPOSE: A method for preparing a pranlukast nano solid dispersant is provided to improve solubility and thermodynamic stability and to suppress recrystallization. CONSTITUTION: A method for preparing a pranlukast nano solid dispersant comprises: a step of uniformly mixing 1g of pranlukast, 2-6g of polyethylene glycol, and 0.1-3g of poloxamer surfactant; a step of fusing and drying the mixture; and a step of dissolving the dried material in a solvent and removing the solvent. The pranlukast nano solid dispersant contains pranlukast, polyethylene glycol, and poloxamer. The particle size of the pranlukast nano solid dispersant is 250-350 nm.