FIBROBLASTS CELLULAR MODEL FOR ASSESSING EFFICACY OF CANCER TREATMENTS BY SHH/PTCH PATHWAY ANTAGONISTS

摘要

ABSTRACT Fibroblasts cellular model for assessing efficacy of cancer treatments by SHH/PTCH pathway antagonists 5 The present invention is in the domain of pharmacy and more specifically in skin cancer area and particular for Basal Cell Carcinoma (BCC). The present invention provides a cellular model targeting the Sonic Hedgehog/Patched (SHH/PTCH) pathway dysregulation or inappropriately activated as well as screening method using this cellular model to screen pharmacological compounds able to treat or prevent BCC lesions.10