ANTIBODIES CONTAINING THERAPEUTIC TPO/EPO MIMETIC PEPTIDES FOR TREATMENT OF THROMBOCYTOPENIA TYPE CONDITIONS

摘要

Disclosed is a therapeutic antibody, or a therapeutically-active fragment of the antibody, wherein the antibody or fragment comprises a light chain polypeptide and a heavy chain polypeptide, wherein the antibody or fragment comprises at least two therapeutic peptides, and wherein at least one of the therapeutic peptides is incorporated into the constant region of the light chain polypeptide at a position that is structurally permissive to allow for the therapeutic peptide to be presented at the central cleft of the antibody. Further disclosed is an isolated nucleic acid encoding: (a) a polypeptide comprising: (i) the amino acid sequence depicted in SEQ ID NO: 10; and (ii) the amino acid sequence depicted in SEQ ID NO: 12; (b) a first polypeptide comprising the amino acid sequence depicted in SEQ ID NO:10 and a second polypeptide comprising the amino acid sequence depicted in SEQ ID NO:12; or (c) a polypeptide comprising the amino acid sequence depicted in SEQ ID NO:10.