发明名称 |
MANIPULATION OF IMMUNOGLOBULIN GENE DIVERSITY AND MULTI-ANTIBODY THERAPEUTICS |
摘要 |
The invention provides improved non-human vertebrates and non-vertebrate cells capable of expressing antibodies comprising human variable region sequences. The present invention is directed to the provision of long HCDR3s from non-human vertebrates and cells. The present invention is also directed to the provision of novel V, D and J pairings in immunoglobulin heavy and light chain loci. Novel, biased antibody diversities and potentially expanded diversities are provided. The invention also provides for novel and potentially expanded diversity or diversity that is biased towards variable gene usage common to antibodies useful for treating and/or preventing certain diseases or conditions, such as infectious diseases. The invention also provides methods of generating antibodies using such vertebrates, as well as the antibodies per se, therapeutic compositions thereof and uses. |
申请公布号 |
CA2846322(A1) |
申请公布日期 |
2013.03.28 |
申请号 |
CA20122846322 |
申请日期 |
2012.09.18 |
申请人 |
KYMAB LIMITED |
发明人 |
FRIEDRICH, GLENN;LEE, E-CHIANG;CLUBE, JASPER;ENGLAND, NICHOLAS |
分类号 |
A01K67/027;C07K16/46;C12N15/85 |
主分类号 |
A01K67/027 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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