发明名称 |
ANTI-HLA-DR ANTIBODIES SUPPRESS ALLOGENEIC AND XENOGENEIC IMMUNE RESPONSES TO ORGAN TRANSPLANTS |
摘要 |
Disclosed herein are methods and compositions comprising anti-HLA-DR antibodies for treatment of allogeneic and xenogeneic immune responses occurring in organ transplant rejection and other immune dysfunction diseases. In preferred embodiments, the anti-HLA-DR antibodies are effective to deplete antigen-presenting cells, such as dendritic cells. Most preferably, administration of the therapeutic compositions depletes all subsets of APCs, including mDCs, pDCs, B cells and monocytes, without significant depletion of T cells. In alternative embodiments, administration of the therapeutic compositions suppresses proliferation of allo-reactive T cells, while preserving cytomegalovirus (CMV)-specific, CD8+ memory T cells. The compositions and methods provide a novel therapeutic agent for suppressing or preventing allogeneic or xenogeneic immune responses, without altering preexisting anti-viral immunity. |
申请公布号 |
WO2013043800(A1) |
申请公布日期 |
2013.03.28 |
申请号 |
WO2012US56224 |
申请日期 |
2012.09.20 |
申请人 |
IMMUNOMEDICS, INC.;SAWADA, TOKIHIKO;CHANG, CHIEN-HSING;GOLDENBERG, DAVID, M. |
发明人 |
SAWADA, TOKIHIKO;CHANG, CHIEN-HSING;GOLDENBERG, DAVID, M. |
分类号 |
A61K39/395 |
主分类号 |
A61K39/395 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|