DIAGNOSIS AND/OR PROGNOSIS OF PARKINSON'S DISEASE DEMENTIA

摘要

The present Invention provides a method for diagnosing and/or prognosing Parkinson's disease dementia (PDD) comprising the step of detecting O-glycosylation. in a protein comprising a Scr/Thr motive, in particular Serpin Al, and/or the level of sialic acid on a protein comprising a Ser/Thr motive, in particular Serpin Al. Further, the present invention relates to a molecule for detecting O-linked glycomoieties in a protein comprising a Ser/Thr motive, in particular Serpin Al, and/or glycosylated i so forms of a Ser/Thr motive comprising protein, in particular Serpin Al" for use in the diagnosis and/or prognosis of Parkinson's disease dementia (PDD), Furthermore, the present invention relates to means for diagnosing and/or prognosing Parkinson's disease dementia (PDD) and a kit for diagnosing and/or prognosing Parkinson's disease dementia (PDD).