| 摘要 |
593811 Provided is a compound having the formula R1-X-Z-R2, wherein R1 is hydrogen, C1-4 alkyl, acetyl, formyl, benzoyl or trifluoroacetyl; X is a peptide which has the formula His-Ser -Gln-Gly-Thr-Phe-Thr -Ser-Asp-Tyr -Ser -Lys-Tyr -Leu-Asp-Arg-Ala-Arg-Ala-Asp-Asp-Phe-ValAla-Trp-Leu-Lys-Glu-Ala, wherein 1-4 specified amino acids can be modified, and Z is absent or a sequence of 1-20 amino acid units selected from the group consisting of Ala, Leu, Ser, Thr, Tyr, Cys, Glu, Lys, Arg, Dbu, Dpr and Orn. The compound can be used to treat or prevent obesity and associated diseases.
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