| 发明名称 |
INFECTIOUS HEPATITIS C VIRUS-HIGH PRODUCING HCV VARIANTS AND USE THEREOF |
| 摘要 |
An objective of this invention is to provide an HCV strain with a high capacity for virus production in a cell culture system. This invention provides a nucleic acid encoding a polyprotein precursor of the hepatitis C virus JFH1 strain having one or more amino acid substitutions, wherein the polyprotein precursor comprises at least substitution of glutamine at position 862 with arginine, as determined with reference to the amino acid sequence as shown in SEQ ID NO: 2 in the Sequence Listing. |
| 申请公布号 |
US2013078277(A1) |
申请公布日期 |
2013.03.28 |
| 申请号 |
US201113636904 |
申请日期 |
2011.03.25 |
| 申请人 |
KITAMURA YOSHIHIRO;SHIMIZU YOKO;AOKI CHIE;YU LIJUAN;WAKITA TAKAJI;THE UNIVERSITY OF TOKYO;NIHON UNIVERSITY;TOKYO METROPOLITAN INSTITUTE OF MEDICAL SCIENCE;TORAY INDUSTRIES, INC.;JAPAN AS REPRESENTED BY DIRECTOR-GENERAL OF NATIONAL INSTITUTE OF INFECTIOUS DISEASES;INSTITUTE OF MICROBIOLOGY, CHINESE ACADEMY OF SCIENCES |
发明人 |
KITAMURA YOSHIHIRO;SHIMIZU YOKO;AOKI CHIE;YU LIJUAN;WAKITA TAKAJI |
| 分类号 |
C12N7/00;A61K39/29;C07K14/18 |
主分类号 |
C12N7/00 |
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