PROCESS FOR FOSAPREPITANT

摘要

In one aspect, the present invention provides a novel process for reducing palladium content in fosaprepitant dimeglumine, which comprises: a) providing a solution of fosaprepitant dimeglumine in a solvent; b) adding SiliaBond Metal Scavenger to the solution obtained in step (a); c) maintaining the reaction mass obtained in step (b); d) adding a solvent to the reaction mass; e) isolating the wet solid; f) slurring the wet solid obtained in step (e) with an ester solvent; and g) isolating fosaprepitant dimeglumine.