摘要 |
<p>The invention relates to a pharmaceutical or nutraceutical formulation comprising a core, comprising an active pharmaceutical or nutraceutical ingredient, a penetration promoter and a bioavailability promoting agent, and a polymeric coating for the gastrointestinal targeted release of the active ingredient, characterized in that the bioavailability promoting agent is a pharmaceutically acceptable inhibitor of proteolytic enzymes, which increases the oral bioavailability of the active ingredient by a factor of at least five, compared to a corresponding formulation without the bioavailability promoting agent.</p> |
申请人 |
EVONIK ROEHM GMBH;LIZIO, ROSARIO;GOTTSCHALK, MICHAEL;DAMM, MICHAEL;WINDHAB, NORBERT;LIEFKE, MELANIE;SCHMITT, GUENTER;ROTH, ERNA;ALEXOWSKY, RUEDIGER |
发明人 |
LIZIO, ROSARIO;GOTTSCHALK, MICHAEL;DAMM, MICHAEL;WINDHAB, NORBERT;LIEFKE, MELANIE;SCHMITT, GUENTER;ROTH, ERNA;ALEXOWSKY, RUEDIGER |