LOGICAL ENZYME TRIGGERED (LET) LAYER-BY-LAYER NANOCAPSULES FOR DRUG DELIVERY SYSTEM

摘要

Nanocapsule compositions comprising a calcium carbonate core surrounded by a bi layer or bi layers of polystyrene sulfonate and poly(aliylamine hydrochloride). The poly(alIy!amine hydrochloride) is conjugate to a substrate, wherein the substrate is capable of being acted upon (for example cleaved) by a biomarker or enzyme associated with a disease state of interest. The nanocapsule compositions may be administered to an animal, for example a human, for the treatment of a disease state.