发明名称 |
Immunosuppression By Blocking T Cell Co-Stimulation Signal 2 (B7/CD28 Interaction) |
摘要 |
The invention provides methods for inhibiting T-cell mediated rejection of a xenotransplanted organ by blocking the delivery of co-stimulatory signal 2 (the B7/CD28 interaction) prevent the activation of xenoreactive T-cells in the recipient. In a first aspect, co-stimulation is prevented by administration to the organ recipient of a soluble form of CTLA-4 from the xenogeneic donor organism. In a second aspect, co-stimulation is antagonised by expressing a ligand for CTLA-4 on the xenogeneic donor cells. In a third aspect, co-stimulation is prevented by expressing recipient organism MHC class II on the surface of the cells of the xenogeneic donor organ.
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申请公布号 |
US2013078266(A1) |
申请公布日期 |
2013.03.28 |
申请号 |
US201113316791 |
申请日期 |
2011.12.12 |
申请人 |
LECHLER ROBERT IAN;DORLING ANTHONY |
发明人 |
LECHLER ROBERT IAN;DORLING ANTHONY |
分类号 |
C07K14/705;A01K67/027;A61K31/7052;A61K35/12;A61K35/14;A61K38/00;A61K38/17;A61K39/00;A61K39/395;A61K48/00;A61P37/06;A61P43/00;C07K16/28;C12N5/10;C12N15/09;C12N15/12 |
主分类号 |
C07K14/705 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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