| 摘要 |
<p>A highly stable crystal of (1S)-1,5-anhydro-145-(4-{(1E)-4-[(14[2- (dimethylamino)ethyl]amino}-2-methyl-1-oxopropan-2-yDamino]-3,3-dimethy1-4-oxobut-1- enThyllbenzyl)-2-methoxy-4-(propan-2-y1)phenylkD-glucitol, and a process for producing the crystal are provided. Specifically, an ethanolate having the following physical properties, and a plurality of other crystal forms transformed from the ethanolate are provided:Having peaks at 20 = 5.9 degrees, 17.1 degrees, 17.6 degrees and 21.5 degrees in X-ray powder diffraction (Cu-Ka);Showing characteristic absorption bands at 3538 cm-4, 3357 cm-i, 2964 cm-1, 1673 cm-1, 1634 cm-1 and 1505 cm-1 in an infrared absorption spectrum; andHaving a melting point in a vicinity of 111°C.</p> |
