发明名称 |
IMPROVED ANTIBODIES OF THE CLASS IGG4 |
摘要 |
<p>The present invention provides an antibody of the class IgG4 comprising at least one heavy chain which comprises a CH1 domain and a hinge region, wherein in each heavy chain: a. the inter-chain cysteine at position 127, numbered according to the Kabat numbering system, in the CH1 domain is substituted with another amino acid; and b. one or more of the amino acids positioned in the upper hinge region is substituted with cysteine.</p> |
申请公布号 |
SG187677(A1) |
申请公布日期 |
2013.03.28 |
申请号 |
SG20130007950 |
申请日期 |
2011.08.19 |
申请人 |
UCB PHARMA S.A. |
发明人 |
HUMPHREYS, DAVID PAUL;PETERS, SHIRLEY JANE;ADAMS, RALPH;HEADS, JAMES |
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